Foresight Engine

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Ensure that all academic journals publish relevant research papers for free online to maximise exposure to novel approaches

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Allow the testing of novel pharma and/or clinical intervention invivo on test subjects that have given informed consent

played over 1 year ago by Michael J Pannell

Antagonism in response to:

stemcell-grown brain tissue to use as treatment, try to graft in new tissue where degradation has occured.

Introduction of Oligodendrocyte precursor cells into locale where Demyelination is progressing fails to resheath effected neurons.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Create brain scanning and uploading technology to preserve minds before they can be destroyed by the prion.

A game runner marked this card Super Interesting.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Invest heavily in Hard AI and bring about the technological singularity, AI many factors more intelligent than humanity can be tasked.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Government funding of academia to focus on relevant science and engineering and not on arts and culture until a cure is found.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

All public sector/government computers to run distributed computing research software to speed up research time.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Global 4g wifi roll out, network the world - increase the number of researchers able to collaborate on this project.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Create brain scanning and uploading technology to preserve minds before they can be destroyed by the prion.

Current experts in this field believe we will have a fully operational reverse engineered human brain by 2030 with existing levels of spend.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Create brain scanning and uploading technology to preserve minds before they can be destroyed by the prion.

2040-2050 before uploading of biological consciousness to this machine brain would be feasible. Would increase spending = reduced time?

played over 1 year ago by Michael J Pannell

Momentum in response to:

Alter funding models -> researchers focus on research & ensure implementation (B4 chasing the next grant)

Will increase research focus and reduce time wasted on administration.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Consider what the physics community does: publish all papers online before submitting to journals. That gets the ideas out sooner

Wide adoption of publication model across academic sector leads to cross proliferation of ideas between the seperate disciplines.

played over 1 year ago by Michael J Pannell

Investigation in response to:

All public sector/government computers to run distributed computing research software to speed up research time.

Yes!

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Government to match funding non profit obtains from citizen donations.

played over 1 year ago by Michael J Pannell

Dark Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Government already struggling to fund long term care of growing number of infected patients without giving money to non profits

played over 1 year ago by Michael J Pannell

Momentum in response to:

DIY bio/biocurious movement expands, developing a non-professional class of researchers

DIYBIO community makes progress on a cure and heralds a new dawn for citizen scientists.

played over 1 year ago by Michael J Pannell

Investigation in response to:

DIY bio/biocurious movement expands, developing a non-professional class of researchers

What can we do to ensure that diybiologists publish their data?

played over 1 year ago by Michael J Pannell

Investigation in response to:

Increase spending on medical research.

How can we ensure that increased spending will not simply lead to increased wastage, how do we guarantee funding is spent appropriately?

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Increase spending on medical research.

Increase spend leads to linear progression not exponential progression as funding is spent on research not developing new tools for analysis

played over 1 year ago by Michael J Pannell

Investigation in response to:

Data and information transparency betwween all institutuions involved, for immediate data sharing and access.

improvements to computer data storage - holographic, electron spin, nanotube tech. Increase funding of data mining and pattern recog softw.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Would this be in addition to current gov't funding model (NIH grants, etc?)

It would be on top of existing funding models and 501(c) status.

played over 1 year ago by Michael J Pannell

Momentum in response to:

What kind of platform is necessary to share research results in real-time? What does real-time mean in this case?

Global adoption of 4g wireless would allow any researcher, anywhere in the world to contribute via upload to a common research portal.

played over 1 year ago by Michael J Pannell

Antagonism in response to:

I'd make treatment/cure a universal right and not just the priviledge of the wealthier few.

Universal healthcare results in obligation to treat any patient for any condition and funding for this project is reduced as a result.

played over 1 year ago by Michael J Pannell

Momentum in response to:

pay primary care docs to cure diseases of defined pt. populations, not treat them - PCPs will pressure pharma to find drugs that "cure"

Primary Care Doctors concentrate on preventing illness rather than treating post infection symptons, improving the nationals general health.

played over 1 year ago by Michael J Pannell

Momentum in response to:

pay primary care docs to cure diseases of defined pt. populations, not treat them - PCPs will pressure pharma to find drugs that "cure"

Doctors focus on keeping people better than well and preventative medicine rather than treating those presenting themselves already sick.

played over 1 year ago by Michael J Pannell

Momentum in response to:

JFYI - B4 we attack disease, we must understand it.->use molecular analysis techniques & software 2better understand disease 2find mol roots

Projects such as 'folding@home' lead to a greater understanding of molecular causes of disease

played over 1 year ago by Michael J Pannell

Momentum in response to:

Introduction of Oligodendrocyte precursor cells into locale where Demyelination is progressing fails to resheath effected neurons.

Alternative approaches such as molecular filtration, applied nanotech, lazer ablation of prions and infected tissue explored.

played over 1 year ago by Michael J Pannell

Momentum in response to:

reducing red tape & more strict policies on ethics for the greater good, at the expense of those who have little to lose

Cutting regulation would expediate getting potential cures to the human test phase.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Artificial Intelligence that surpassing human understanding

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Sphere Fluidics for sample analysis

played over 1 year ago by Michael J Pannell

Momentum in response to:

Use neurons from stem cells to test possible treatments in vitro

Creation of new stem cell lines/ability to potentiate specific human tissue groups = reduced need for animal models = less risk to humans

played over 1 year ago by Michael J Pannell

Investigation in response to:

What's that?

http://www.youtube.com/watch?v=AajNacI_HEo&feature=youtube_gdata

played over 1 year ago by Michael J Pannell

Investigation in response to:

Sphere Fluidics for sample analysis

Ultra high throughput automated screening process for biological samples

played over 1 year ago by Michael J Pannell

Momentum in response to:

Nanotechnology, combining materials science and biological science may introduce the most promising therapies.

Applying engineering processes to biological problems revolutionises molecular biology, advances in nanotech open up new avenues of research

played over 1 year ago by Michael J Pannell

Momentum in response to:

While trying to accelerate cures, how do we deal with devastating consequences if no cure is found & 100M patients need care in 7-10 yrs?

Implementation of advanced directives results in a significant number of infected people opting to euthanise/DNR policies.

played over 1 year ago by Michael J Pannell

Momentum in response to:

While trying to accelerate cures, how do we deal with devastating consequences if no cure is found & 100M patients need care in 7-10 yrs?

Volunteers are put into induced comas and then used as 'living' research specimens.

played over 1 year ago by Michael J Pannell

Adaptation in response to:

While trying to accelerate cures, how do we deal with devastating consequences if no cure is found & 100M patients need care in 7-10 yrs?

Whilst no cure is found in the first 7-10 years, treatments are discovered that partially regenerate myelin, reducing the need for care.

played over 1 year ago by Michael J Pannell

Investigation in response to:

At what stage of clinical testing would the pharma/clinical intervention have to be at to be stable enough for in vivo use?

I suppose that would be dependant on how desperate we got for a cure and on a test subjects remaining life expectancy

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Allow researchers access to "live" clinical databases (of patients currently in treatment) to vastly increase the amount of data available.

Contraindication between their current treatment regime and any proposed novel treatment could be a significant negative issue.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

deregulation of existing legal controls

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Additional tax breaks to corps that donate their last generation of lab equipment/computer hardware when they buy new.

A game runner marked this card Super Interesting.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Allow citizen scientists/amateurs to use lab space at high schools/universities when not in use by those institutions.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Encourage academic journals to publish research from amateurs if it meets a standard,do not insist on academic affiliation.

A game runner marked this card Super Interesting.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Government to introduce a prize fund for advances made to science by amateus/citizen scientists in the field of medical research.

A game runner marked this card Super Interesting.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Summary: Treat all clinical trials as research in the public interest

Expand by ensuring that all clinical data is published in the public domain

played over 1 year ago by Michael J Pannell

Investigation in response to:

Do journals only accept submissions from academics?

Some do, some don't, there does not appear to be a standardised approach.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Create a science/medical research journal that doesn't judge science submissions based on researcher's credentials instead other metrics.

Great Idea!

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Peer review should become peer collaboration. You don't comment others' work, you go there and actively help them; only after you rate them.

Competition is oft the driving force that encourages development. Would collaboration achieve better results?

played over 1 year ago by Michael J Pannell

Dark Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Working in isolation, obsession with protecting patents, protecting formulae etc, all of this restricts progression.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Or set up collective-type labs where people can have access to shared equipment. Give manufacturers incentives to provide at low cost.

Indeed, apply the hackspace approach to amateur bioscience

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Provide a free 'online university' that would allow amateurs and citizen scientists to obtain academically valuable qualifications.

A game runner marked this card Super Interesting.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Provide a free 'online university' that would allow amateurs and citizen scientists to obtain academically valuable qualifications.

Existing academics could provide supervision for experimental course work at a community hack space in exchange for research assistance.

A game runner marked this card Super Interesting.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Encourage Pharmacorps to take on more interns, encourage academic institutions to allow students to take a 'working gap year' in their field

played over 1 year ago by Michael J Pannell

Investigation in response to:

Introduction of Oligodendrocyte precursor cells into locale where Demyelination is progressing fails to resheath effected neurons.

Suggestions for alternative treatments/therapies than required!

played over 1 year ago by Michael J Pannell

Momentum in response to:

Create the 1-1 computational model of the human being at chemical level. Pool ICT efforts worldwide to this purpose, in a 5-years project

Bring the technical singularity about quicker.

played over 1 year ago by Michael J Pannell

Momentum in response to:

How do you filter for bad data?

As the data would be shared and the research methods shared it would allow for peer review/replication of experiement to test viability

played over 1 year ago by Michael J Pannell

Momentum in response to:

As the data would be shared and the research methods shared it would allow for peer review/replication of experiement to test viability

Any erroneous data would then be marked for removal.

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Invest on the development of more accurate biochemical sensors; that would not only measure variables, but also upload them to a database.

Biochemical sensors are already extremely accurate. Without substantial gains in AI to speed up analysis we have researched a glass ceiling.

played over 1 year ago by Michael J Pannell

Investigation in response to:

By allowing more end of life patients to enroll without their death creating a negative mark on the treatment under trial.

Could you envisage any situations where the need for informed consent would be bypassed in the global public interest?

played over 1 year ago by Michael J Pannell

Momentum in response to:

Current models of medical education stifle creativity, inquiry and innovation.

Allow medical students to specialise much earlier in their career... choosing to go into Surgery/General Medicine/ etc/ etc from outset

played over 1 year ago by Michael J Pannell

Investigation in response to:

Collaborate many clinics to work together to have multiple trials at once rather than one at a time.

Are you suggesting using the same group of test subjects? As there could be contraindication between pharma/surgical intervention tested

played over 1 year ago by Michael J Pannell

Momentum in response to:

Improved information management systems that allow up-to-date medical research to be summarized and delivered directly to mobile devices.

20mbit+ internet globally with public access, and android 2.0+ capable mobile devices or equilent would see this realised.

played over 1 year ago by Michael J Pannell

Momentum in response to:

What ethical requirements are barriers that need lowering?

Advanced Directive made with informed consent should be valid once mental competancy is later lost.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Encouraging MD/PhD track students (as apposed to MD track) would educate a generation of doctors INTERESTED in conducting research trials.

Would you encourage much earliar specialistion? Selectives from day 1 at Medical School?

played over 1 year ago by Michael J Pannell

Momentum in response to:

Instead, use stem cell research to create cell lines with specific biomarkers.

Progress this to the next step, potentiate stem cells into tissue cultures so these can be used instead of live subjects or animal models.

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Make biology/basic science an hour long course starting at the second grade. Little kids have sponge-brains,

Should be much longer than 1 hour! What are they wasting time teaching them for the rest of the day?

played over 1 year ago by Michael J Pannell

Momentum in response to:

Channel resources to the countless hospitals in underdeveloped countries that have access to patients but lack funding for clinical trials.

We would need to ensure that the same quality standards and ethical standards were followed.

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Encouraging MD/PhD track students (as apposed to MD track) would educate a generation of doctors INTERESTED in conducting research trials.

I think that rather than doing a PhD alongside the MD, allowing specialisation from early on (pre clinical) would free up time for research

played over 1 year ago by Michael J Pannell

Momentum in response to:

Educate/mentor more MDs on running clinical trials (inc med ed and CME relating to clin research).

Research Skills/Clinical Audit course should be a compulsory module at Medical School not an elective option.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Consider a structure that fosters competition and collaboration, at the same time. Elsewhere, I will introduce the "bucket brigade"

Ideal, they undoubtedly best in synergy.

played over 1 year ago by Michael J Pannell

Adaptation in response to:

no...I think the "publish or perish" problem is more like what I was thinking of. Academia can be a scary place with that attitude :-)

The publish or perish model is flawed as oft leads to rushed research

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Make insurance companies cover experimental treatments

Would lead to increased premiums and selective treatments based on $/value as opposed to what works best.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Encourage companies to start trials with oral formulations- that will allow higher patient enrollment and less infrastructure issues.

Do other drug delivery methods require additional infrastructure then?

played over 1 year ago by Michael J Pannell

Investigation in response to:

Do other drug delivery methods require additional infrastructure then?

Do you mean more people would be willing to volunteer for trials if these trials didn't require injections/blood samples/biopsy sampling?

played over 1 year ago by Michael J Pannell

Momentum in response to:

It also leads to straight up lies... http://tinyurl.com/35fe5kb

If the practices referred to in that article are entrenched throughout the medical sector at the rates described then = time for new model!

played over 1 year ago by Michael J Pannell

Antagonism in response to:

IV requires hospitals. Oral is easier. Once you are past Phase I and you know the drug is safe you can give it anywhere.

Diabetics inject at home, even intravenous drug addicts can work a syringe, test subjects can be taught how to self administer if need be.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Makes me wonder if something about the way biology/science was taught changed that we distinguished it as "work" and not "play/fun".

Applies to mathematics as well. Badly taught kids hate learning, well educated kids thrive on new material.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Create a secure eHealth platform, SDK and data aggregator and invite the open source community to create apps for crowdsource analysis.

This is an outstanding idea.

played over 1 year ago by Michael J Pannell

Momentum in response to:

I was mainly thinking that it would be easier to organize trials in less developed countries= more pts.

I could see that leading to more participants volunteering for trial.

played over 1 year ago by Michael J Pannell

Momentum in response to:

IP-enable everything that can provide real-time impact to health (e.g. removal of ice cream from fridge alerts mobile health coach)

Global adoption of IPv6 and 4G wireless networks will allow every object to have its own connection to faciliate such a system

played over 1 year ago by Michael J Pannell

Antagonism in response to:

Public will assume this is just one more "cry wolf" health scare; SARS, H1N1, etc. and fail to take appropriate public health actions.

And soon change their minds when they see their fellow citizens dropping like flies sprayed with raid.

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

BioPharma to provide research academics with nootrophics/cognitive enhancers so they can work harder/longer - shortening research times.

A game runner marked this card Super Interesting.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Grow brain trusts through guilds and online quest games such as this one

Collaborative brainstorming such as this should become a standard project tool.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Hard work is not the solution. Great inventions are rather made by creative minds which were given the chance to realize their visions.

What if the nootrophic enhanced cognitive process/creativity?

played over 1 year ago by Michael J Pannell

Investigation in response to:

Fund BioPharma to hire academics that actually have the disease they are researching... a very strong motivator for success.

Would you take this as far as deliberately infecting scientists already working in that specific field to encourage them to work harder?

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Primary care provider to upload all 'personal genomic data' from patients with the prion disorder to speed up development of cure

played over 1 year ago by Michael J Pannell

Positive Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Primary care provider to upload all 'personal genomic data' from patients with the prion disorder to speed up development of cure

played over 1 year ago by Michael J Pannell

Momentum in response to:

Most of the times that happened in Europe "clever" businessmen use such captital for personal gain enraging the public.

A condition of being given seed capital would be a clawback clause where the businessman was liable to repayment if spent it on lifestyle.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Primary care provider to upload all 'personal genomic data' from patients with the prion disorder to speed up development of cure

Should consent be an issue or should legislation be adopted making this compulsory?

played over 1 year ago by Michael J Pannell

Investigation in response to:

Do more trials with placibos

Do not all trials involving pharmaceutical interventions already have placibos as part of the test cycle?

played over 1 year ago by Michael J Pannell

Momentum in response to:

We need to be united as HUMAN BEINGS, to work on solutions...not separated by location, citizenship, money, prestige, power, politics, war

The adoption IPv6 and Global 4G WIFI will connect all of humanity and usher in a period of collaboration never before seen in human history.

played over 1 year ago by Michael J Pannell

Momentum in response to:

To handle this trouble, we need to create a new culture, one that empathizes sharing knowledge instead of hiding it.

This should be a core priniciple of scientific endeavor

played over 1 year ago by Michael J Pannell

Investigation in response to:

Good instructors often don't succeed at research U's. Give credit to instructors by recording their student pubs as a qualitative assesment.

Are not academic institutions/faculty already graded on teaching quality and research quality?

played over 1 year ago by Michael J Pannell

Antagonism in response to:

provide every household with their own "scientific start up kit" for home experimentation on a cure

Billions of dollars lost providing boxes of research equipment to a general populus that has no intention of engaging in research.

played over 1 year ago by Michael J Pannell

Adaptation in response to:

provide every household with their own "scientific start up kit" for home experimentation on a cure

Fund any organisation already in a position to undertake research but lacking specific equipment to research this prion disorder.

played over 1 year ago by Michael J Pannell

Adaptation in response to:

provide every household with their own "scientific start up kit" for home experimentation on a cure

Screen requests for startup kits to ensure they are going to people with a genuine interest/potential to find a cure, not just to randoms.

played over 1 year ago by Michael J Pannell

Antagonism in response to:

create bio-dome where people are given the best foods, exercise regime, relaxation support, social connections and track their disease path

This would take too long to gain data from test subjects due to slow decline in mental function with this neurodegenerative disease.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Doctors focus on keeping people better than well and preventative medicine rather than treating those presenting themselves already sick.

played over 1 year ago by Michael J Pannell

Investigation in response to:

Doctors focus on keeping people better than well and preventative medicine rather than treating those presenting themselves already sick.

Doctors should primarily focus on preventative medicine, keeping people better than well and then on treatement.cures as a last resort

played over 1 year ago by Michael J Pannell

Dark Imagination in response to:

How would you advise the President to reinvent the process of medical discovery?

Ethics committees restricting research based on their moral values and not the overwhelming public need.

played over 1 year ago by Michael J Pannell

Momentum in response to:

facilitate worldwide hub innovation sessions http://socialentrepreneurship.change.org/blog/view/the_hub_and_spaces_for_social_change

Hackerspaces expanded into cyberspace with virtual meeting rooms for people to collaborate research ideas

played over 1 year ago by Michael J Pannell

Momentum in response to:

Create more CO-OP based insurance companies. Where they are patient owned and membership payments aren't lost as dividend.

This is a great idea for funding private healthcare insurance.

played over 1 year ago by Michael J Pannell

Momentum in response to:

the available funds and knowledgeable minds to find a cure are located in countries with too many regulations and competing interests

Changes to legislation and relaxation of regulations open up new avenues to researching a cure.

played over 1 year ago by Michael J Pannell

Antagonism in response to:

the available funds and knowledgeable minds to find a cure are located in countries with too many regulations and competing interests

Changes to legislation and safety/ethics regulations result in public concerns of rights infringements, utilitarianism etc

played over 1 year ago by Michael J Pannell

Adaptation in response to:

the available funds and knowledgeable minds to find a cure are located in countries with too many regulations and competing interests

Public consultation prior to relaxation of regulations results in overwhelming public support for change, speeding up the search for a cure.

played over 1 year ago by Michael J Pannell

Investigation in response to:

the available funds and knowledgeable minds to find a cure are located in countries with too many regulations and competing interests

Would you propose moving research to countries with less/no restrictions or instead relaxing/deregulating controls within the US?

played over 1 year ago by Michael J Pannell

Momentum in response to:

Incentives for deferring post-MD or PhD to design short (1-3yr) projects in collaboration with other recent grads with different expertise.

Financial support for this to cover living costs of participants would allow some amazing collaborative projects to be undertaken.

played over 1 year ago by Michael J Pannell

Momentum in response to:

Incentives for deferring post-MD or PhD to design short (1-3yr) projects in collaboration with other recent grads with different expertise.

Extend to MSc/MRes/MEng not just MD/PhD

played over 1 year ago by Michael J Pannell

Played

Tracked